The MCA is housed in two separate buildings, which are connected by a glass-roofed corridor: the Main Building, housing the permanent
collections and the New Wing, and the Stathatos Mansion, housing the temporary exhibitions.
The Stathatos Mansion, work of the Bavarian architect Ernst Ziller, is one of the most important extant examples of Neoclassical architecture in nineteenth-century Athens. Since 1991 it houses temporary exhibitions and the offices of the museum. The building is accessible both from the corner of Vasilissis Sophias Avenue and Irodotou Street, and from the Main Building, via a closed passageway leading from the atrium.
The Main Building, at 4 Neophytou Douka str., was built in 1985 by the architect Ioannis Vikelas to house the permanent collections of the MCA. The builidng has 4 floors with galleries, occupying in total approximately 2,300 sq. m., storerooms, workshops, and offices.